*’Nano’ means….
Nanometer: one billionth of a meter
Nano-: prefix comes from the Greek word for ‘dwarf’
Chemical, physical, and biological properties that differ from those of their larger, or bulk counterparts
Nanotechnology: The National Nanotechnology Initiative(NNI)-> the science of materials and phenomena in the range of 1 to 100nm in diameter
*Features of ‘nanoparticles
Nanoparticles present possible dangers
- due to the high surface to volume ratio
pass through cell membranes in organisms
Smaller nanoparticles evinced increased cytotoxicity.
Self-assembly :
process that disordered system of components forms an organized structure or pattern
The device is switched on - >
the pump pushes ions across the lipid membrane,
nanoparticles that can carry the drug molecules to the target safely.
5.2.2 Nanocarriers - Nanoparticles
Before starting with the functionalization of nanoparticles, it is important to keep in mind a range of useful properties we wish to have in any drug delivery across the BBB(Blood brain barrier). In this context, owing to their small size, customizable surface, improved solubility, tar
B. Solution-Liquid-Solid Growth of Indium Phosphide Fibers from Organometallic Precursors: Elucidation of Molecular and Nonmolecular Components of the Pathway
Solution-phase organometallic syntheses of semiconductors are used for the growth of high-quality quantum dots,1-3 and are potentially useful for the deposition of semiconductor materials on thermally sensitive substrates such as polymers
1. Nanorods
of the reported procedures for rod formation, seedmediated growth has been by far the most efficient and popular approach. The role played by the seed particle is also critical. Furthermore, the presence of small amounts or silver nitrate during the synthesis has a dramatic effect on the final shape and crystalline structure if the particles. Citrate-capped gold nanoparticle, prepare
Lipid
ETC.
Non-Biological
Laser Process
((약물 or 약 or 치료물질) and (전달 or 전달자 or 시스템) and (목표 or 변형 or 특이성))
((drug or material or treatment ) and (delivery or carrier or system) and (target or specific or nanoparticle))
약물의 효능이 발휘하는 곳을 targeting 할 때 non-biological한 재료를 사용하는 약물전달시스템
Non-Biolo
Liposomes
Liposomes are artificially prepared vesicles made of lipid bilayer.
Liposomes can be filled with drugs, and used to deliver drugs for cancer and other diseases.
Liposomes are composite structures made of phospholipids and may contain small amounts of other molecules.
Nano-particle drug carriers
Nano-particles are colloidal particles that range in size from 10 to 1000 nm i
주제
Micro-encapsulation을 이용한 생체적합성
나노 파티클 제조 및 특성분석
목표
1. Atomizer 이용한 농도 별 Pluronic 입자 제조
2. Micro-encapsulation 이용한 Pluronic 캡슐 제조
3. 시간에 따른 나노입자 크기변화와 분산 안정성 비교를 통한 encapsulation efficiency 비교
4. 온도에 따른 Pluronic 방
많은 항암제가 천연물로부터 얻어진다. 천연물은 그 자신이 살아가는 데 필요한 1차 대사산물 뿐만 아니라 식물의 종에 따라 한정적으로 분포하는 2차 대사산물을 모두 가지고 있다. 2차 대사산물에는 alkaloid, glycoside, terpenoid 등이 있으며 이 중 2차 대사산물은 유효성분을 포함하여 사람에게 유익한 역